Amphidinolides: Summary of Structural Features, Biological Activity, and Total Syntheses Completed

    Ring Size Ring Type #THF/THP Structure Known L1210 KB HCT Total Synthesis
1 Amphidinolide A 20     Yes 2.0 5.7   Yes
2 Amphidinolide B1 26 B   Yes (X-ray) 0.00014 0.0042 0.122 Yes
3 Amphidinolide B3 26 B   Yes -- -- 0.206 no
4 Amphidinolide B4 26 B   Yes 0.00012 0.001 -- no
5 Amphidinolide B5 26 B   Yes 0.0014 0.004 -- no
6 Amphidinolide B6 26 B   Yes DG-75: 0.02 -- -- no
7 Amphidinolide B7 26 B   Yes DG-75: 0.4 -- -- no
8 Amphidinolide C 25 C 2 THF Yes 0.0058 0.0046   no
9 Amphidinolide C2 25 C 2 THF Yes 0.8 3   no
10 Amphidinolide D (aka B2) 26 B   Yes 0.019 0.08 7.5 no
11 Amphidinolide E 19   1 THF Yes 2.0 L5178Y: 4.8   Yes
12 Amphidinolide F 25 C 2 THF No 1.5 3.2   no
13 Amphidinolide G 27 B   Yes 0.0054 0.0046   Yes
14 Amphidinolide G2 27 B   Yes 0.3 0.8   no
15 Amphidinolide G3 27 B   Yes 0.72 1.3   no
16 Amphidinolide H 26 B   Yes (X-ray) 0.00048 0.00052   Yes
17 Amphidinolide H2 26 B   Yes 0.06 0.06   no
18 Amphidinolide H3 26 B   Yes 0.002 0.022   no
19 Amphidinolide H4 26 B   Yes 0.18 0.23   no
20 Amphidinolide H5 26 B   Yes 0.2 0.6   no
21 Amphidinolide J 15 J   Yes 2.7 3.9   Yes
22 Amphidinolide K 19   1 THF Yes 1.65 2.9   Yes
23 Amphidinolide L 27 B 1 THP Yes 0.092 0.1   no
24 Amphidinolide M 29   2 THF No 1.1 0.44   no
25 Amphidinolide N 26 N 1 THP No 0.00005 0.00006   no
26 Caribenolide I 26 N 1 THF/1 THP No -- -- 0.001 no
27 Amphidinolide O 15 O 1 THF Yes 1.7 3.6   no
28 Amphidinolide P 15 O 1 THF Yes 1.6 5.8   Yes
29 Amphidinolide Q 12     Yes 6.4 >10   no
30 Amphidinolide R 14 J   Yes 1.4 0.67   Yes
31 Amphidinolide S 15 J   Yes 4 6.5   no
32 Amphidinolide T1 19   1 THF Yes 18 35   Yes
33 Amphidinolide T2 19 T 1 THF Yes 10 11.5   no
34 Amphidinolide T3 19 T 1 THF Yes 7.0 10   Yes
35 Amphidinolide T4 19 T 1 THF Yes 11 18   Yes
36 Amphidinolide T5 19 T 1 THF Yes 15 20   Yes
37 Amphidinolide U 20 A,C 1 THF No 12 20   no
38 Amphidinolide V 14     Yes 3.2 7   Yes
39 Amphidinolide W 12     Yes 3.9 --   Yes
40 Amphidinolide X 16   1 THF Yes 0.6 7.5   Yes
41 Amphidinolide Y 17 X 1 THF Yes 0.8 8.0   Yes

Amphidinolide References


By: Brian J. Myers
Please let me know if you find this information helpful
or if you find other references that I have not listed.

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Last Updated: November 24, 2008